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1. Identificação
Tipo de ReferênciaArtigo em Revista Científica (Journal Article)
Sitemtc-m21b.sid.inpe.br
Código do Detentorisadg {BR SPINPE} ibi 8JMKD3MGPCW/3DT298S
Identificador8JMKD3MGP3W34P/3M3ADKH
Repositóriosid.inpe.br/mtc-m21b/2016/07.08.12.52   (acesso restrito)
Última Atualização2016:07.08.12.53.34 (UTC) simone
Repositório de Metadadossid.inpe.br/mtc-m21b/2016/07.08.12.52.15
Última Atualização dos Metadados2024:05.08.19.53.59 (UTC) simone
DOI10.2147/IJN.S106339
ISSN1176-9114
Chave de CitaçãoRodriguesLCSMCWL:2016:ChBiEv
TítuloGraphene oxide/multi-walled carbon nanotubes as nanofeatured scaffolds for the assisted deposition of nanohydroxyapatite: characterization and biological evaluation
Ano2016
MêsJune 13
Data de Acesso12 maio 2024
Tipo de Trabalhojournal article
Tipo SecundárioPRE PI
Número de Arquivos1
Tamanho6735 KiB
2. Contextualização
Autor1 Rodrigues, Bruno V. M.
2 Leite, Nelly C. S.
3 Cavalcanti, Bruno das Neves
4 Silva, Newton S. da
5 Marciano, Fernanda R.
6 Corat, Evaldo José
7 Webster, Thomas J.
8 Lobo, Anderson de Oliveira
Identificador de Curriculo1
2
3
4
5
6 8JMKD3MGP5W/3C9JH33
Grupo1
2
3
4
5
6 LAS-CTE-INPE-MCTI-GOV-BR
Afiliação1 Universidade do Vale do Paraíba (UNIVAP)
2 Universidade do Vale do Paraíba (UNIVAP)
3 University of Michigan
4 Universidade do Vale do Paraíba (UNIVAP)
5 Universidade do Vale do Paraíba (UNIVAP)
6 Instituto Nacional de Pesquisas Espaciais (INPE)
7 Northeastern University
8 Universidade do Vale do Paraíba (UNIVAP)
Endereço de e-Mail do Autor1
2
3
4
5
6 evaldo.corat@inpe.br
RevistaInternational Journal of Nanomedicine
Volume11
Páginas2569-2585
Nota SecundáriaA2_FARMÁCIA A2_CIÊNCIAS_BIOLÓGICAS_I B1_MEDICINA_I B1_CIÊNCIAS_BIOLÓGICAS_II B1_ASTRONOMIA_/_FÍSICA C_QUÍMICA C_BIOTECNOLOGIA
Histórico (UTC)2016-07-08 12:53:34 :: simone -> administrator :: 2016
2018-06-04 02:40:59 :: administrator -> simone :: 2016
3. Conteúdo e estrutura
É a matriz ou uma cópia?é a matriz
Estágio do Conteúdoconcluido
Transferível1
Tipo do ConteúdoExternal Contribution
Tipo de Versãopublisher
Palavras-ChaveBactericidal effect
Bioactivity
Bone cells
Graphene oxide
In vitro
Multi-walled carbon nanotubes
Nanohydroxyapatite
Tissue engineering
ResumoNanohydroxyapatite (nHAp) is an emergent bioceramic that shows similar chemical and crystallographic properties as the mineral phase present in bone. However, nHAp presents low fracture toughness and tensile strength, limiting its application in bone tissue engineering. Conversely, multi-walled carbon nanotubes (MWCNTs) have been widely used for composite applications due to their excellent mechanical and physicochemical properties, although their hydrophobicity usually impairs some applications. To improve MWCNT wettability, oxygen plasma etching has been applied to promote MWCNT exfoliation and oxidation and to produce graphene oxide (GO) at the end of the tips. Here, we prepared a series of nHAp/MWCNT-GO nanocomposites aimed at producing materials that combine similar bone characteristics (nHAp) with high mechanical strength (MWCNT-GO). After MWCNT production and functionalization to produce MWCNT-GO, ultrasonic irradiation was employed to precipitate nHAp onto the MWCNT-GO scaffolds (at 13 wt%). We employed various techniques to characterize the nanocomposites, including transmission electron microscopy (TEM), Raman spectroscopy, thermogravimetry, and gas adsorption (the BrunauerEmmettTeller method). We used simulated body fluid to evaluate their bioactivity and human osteoblasts (bone-forming cells) to evaluate cytocompatibility. We also investigated their bactericidal effect against Staphylococcus aureus and Escherichia coli. TEM analysis revealed homogeneous distributions of nHAp crystal grains along the MWCNT-GO surfaces. All nanocomposites were proved to be bioactive, since carbonated nHAp was found after 21 days in simulated body fluid. All nanocomposites showed potential for biomedical applications with no cytotoxicity toward osteoblasts and impressively demonstrated a bactericidal effect without the use of antibiotics. All of the aforementioned properties make these materials very attractive for bone tissue engineering applications, either as a matrix or as a reinforcement material for numerous polymeric nanocomposites.
ÁreaFISMAT
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4. Condições de acesso e uso
Idiomaen
Arquivo Alvorodrigues_graphene.pdf
Grupo de Usuáriossimone
Grupo de Leitoresadministrator
simone
Visibilidadeshown
Permissão de Leituradeny from all and allow from 150.163
Permissão de Atualizaçãonão transferida
5. Fontes relacionadas
Repositório Espelhourlib.net/www/2011/03.29.20.55
Unidades Imediatamente Superiores8JMKD3MGPCW/3ESR3H2
Lista de Itens Citandosid.inpe.br/bibdigital/2013/09.24.19.30 3
sid.inpe.br/mtc-m21/2012/07.13.14.45.37 3
DivulgaçãoWEBSCI; PORTALCAPES; SCOPUS.
Acervo Hospedeirosid.inpe.br/mtc-m21b/2013/09.26.14.25.20
6. Notas
Campos Vaziosalternatejournal archivingpolicy archivist callnumber copyholder copyright creatorhistory descriptionlevel e-mailaddress format isbn label lineage mark nextedition notes number orcid parameterlist parentrepositories previousedition previouslowerunit progress project rightsholder schedulinginformation secondarydate secondarykey session shorttitle sponsor subject tertiarymark tertiarytype url
7. Controle da descrição
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